At the show page for NH NPR's The Socrates Exchange, you can hear me, BA director Zachary Bos, opine on the meaning of life, from 26:45-31:00. I'm sure the zampolits will tell me if I deviate from Atheist Command's official dogma. (Direct link to audio file here)
Quick answer: yes, life is *ultimately* meaningless, but so what? There are more than enough kinds of subjective, personal, human-sized meaning to keep ourselves busy with.
I had this answer ready where I talk about the impressive ways our Boston Atheists members flaunt the old idea that a life without gods is a life devoid of meaning, but it isn't in the final cut of the show. Too bad -- it would be have good to hear about we've got folks who are raising kids, who volunteer, who work in fields with low pay but high yield of social benevolence, who possess sophisticated views of the universe and their place in it, etc. Long story short: it's real nice to be a part of this crowd.